Department of Immunology and Medicine: Research Efforts and Partners

Product Development 2010-2011

• Drug

• Dihydroartemisinin-piperaquine malaria prophylaxis
• Pharmacokinetics-toxicology: new anti-malarial compounds

• Vaccine

• Pre-clinical studies 
• Archived serum screening – influenza antibodies
• Effect of 2 seasonal flu vaccine doses
• Adjuvant optimization  

• Drug and Vaccine

• P. vivax human challenge model

• Diagnostic

• JBAIDS: malaria and leptospirosis

Surveillance 2010-2011
• P. falciparum malaria
  • in vitro drug resistance

• Thailand, Cambodia

• • in vivo artemisinin treatment responses

• AFRIMS, USAMRU-Kenya 

• H5N1 influenza, Cambodia 

Bench Efforts 2010-2011

• Molecular
  • Pf drug resistance
    • Single gene candidates
    • Genome wide association studies (GWAS)
    • Parasite population analysis; gene flow
    • Multiplicity of infection, polymorphic variant analysis
• G6PD 

• G6 PD-deficiency prevalence in Cambodia
• Polymorphism analysis

• JBAIDS: malaria and leptospirosis
  • Assay development / validation
    • Partner with Idaho Technologies Incorporated (ITI)
  • Clinical pathway to FDA approval

Royal Thai Army - Malaria Microscopy Training 2010

Royal Thai Army

Joint efforts between US and Royal Thai Army components

• P. vivax human challenge model
• Border surveillance
• Treatment responses after standard of care
• Training: microscopy, drug sensitivity

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