Foreword H.E. Sunthorn Hongladarom Secretary-General, SEATO	i
Preamble MAJOR GENERAL Thutchai Dhirathumrong, MC, RTA Director General SEATO Medical Research Project	ii

VIRUS DISEASES OF MAN AND ANIMALS	1
Dengue Infection at the Children’s Hospital of Bangkok	3
Surveillance of Dengue Hemorrhagic Fever Cases in Thailand, 1973 and 1974	10
Dengue Virus Isolation from Human Plasma Inoculated Into Mosquitoes	19
Rapid Detection of Dengue Virus Antigen and Antibody by Counterimmunoelectrophoresis (CEP)	22
The Pathogenesis of Dengue Hemorrhagic Fever. The Role of Biological Mediators: Histamine and Serotonin	24
Radioimmune Assay Inhibition Test for the Detection of Antibody to Hepatitis B Surface Antigen	27
Anti-Hepatitis B Serum Production in Laboratory Animals	34
Hepatitis B Virus Infections in Americans in Southeast Asia	39-
Continuing Studies of Hepatitis B Antigen Carriers in Thailand	44
The Effect on the Offspring of Maternal Hepatitis B Surface Antigenemia	48
Hepatitis B Virus in Bangkok Families	52
Hepatitis B Surface Antigen in Laboratory Reared Mosquitoes	55
Tentative Identification of Langat Virus	57
Experimental Infection of Gibbons with a Group B Arbovirus (T-1674)	60
A Survey for Human Antibody to T-1674	64
Epidemic Influenza in A Hill Tribe in Northwest Thailand	69
Rabies Exposure During Pregnancy	79
Animal Rabies in Thailand: Rabies Diagnostic Laboratory Services	81
Prevalence of Some Viral Infections in the Residents of Phnom-Penh	82
Psittacosis in Birds and Man	88

BACTERIAL DISEASES OF MAN AND ANIMALS	89
Changing Penicillin Resistance of the Gonococcus in Thailand	91
Oropharyngeal Gonorrhea During Pregnancy	97
Effect of a Copper-Containing Intrauterine Device on Neisseria gonorrhoeae in vitro	98
Microbial Flora Present in the Anterior Urethra of Venereal Disease Patients	100
An Epidemiological Survey of Males with Urethritis Attending a Military VD Clinic in Thailand	103
Resistance of Gibbons (Hylobates lar) to Gonococcal Infection	104
Clinical Observation of Vibrio parahemolyticus Infection in Thailand	105
Cholera Study at Samutsongkram	110
Detection of Specific Bacterial Antigen by Counterimmunoelectrophoresis (CEP)	112
Antibiotic-Resistant Typhoid Fever	115
Frequency of Glucose-6-Phosphate Dehydrogenase Deficiency (G-6-PD) Among Infectious Diseases and Control Patients at Children’s Hospital	119
Surveillance of Plague in Thailand	121
Mycoplasma pneumoniae Study	122

PARASITIC DISEASES OF MAN AND ANIMALS	123
Ecology of Bancroftian Filariasis	125
Evaluation of Experimental Antimalarial Drugs in Rhesus Monkeys Infected with Plasmodium cynomolgi	134
Relationship between Erythrocytic Adenosine Triphosphate (ATP) Level and Human Malaria	137
Studies of New Experimental Intermediate and Paratenic Hosts and Modes of Transmission of Gnathostoma spinigerum	139
Chemotherapy of Gnathostomiasis	141
Toxoplasmic Lymphadenitis	144

MISCELLANEOUS	145
An Epizootic of Tropical Canine Pancytopenia in Thailand	147
Prediction of illicit Drug Use by United States Servicemen	154
A Behavioral Survey of Thai Prostitutes	155
Mosquito Fauna of Thailand	156
Pathogens of Medically Important Mosquitoes of Thailand	157
Evaluation of Systemic Insecticides for Control of Trombiculid Mites	159
Studies on the Growth, Development, and Reproduction of Gibbons in Captivity	164
Laboratory Animal Disease in Thailand: Its Occurrence and Importance to Comparative Medicine	167
Vertebrate Reservoirs of Disease	170
Migratory Animal Pathological Survey	175

MALARIA STUDIES	177
The Suppression of Plasmodium falciparum and Plasmodium vivax Parasitemias by a Diformyldapsone-Pyrimethamine Combination	179
The Suppression of Plasmodium falciparum and Plasmodium vivax Parasitemias by a Sulfadoxine-Pyrimethamine Combination	185
Evaluation of the Sporontocidal Activity of Pyrimethamine-Sulfadoxine (Fansidar) Against P. falciparum in Thailand	186
Hospital Survey of Malaria in Trad Province, Southeast Thailand	188
Amodiaquine Resistant Falciparum Malaria in Thailand	191
Falciparum Malaria Semi-resistant to Clindamycin	199
Single-Dose Therapy of Falciparum Malaria Using Pyrimethamine in Combination with Diformyldapsone or Sulfadoxine	206
Falciparum Malaria Cured by Quinine Followed by Fansider (Sulfadoxine with Pyrimethamine)	213
Comparison of Mefloquine (WR 142490) and Pyrimethamine with Sulfadoxine in the Single-Dose Treatment of Falciparum Malaria	219
The Management of Coma in Falciparum Malaria	224
Pulmonary Edema Due to Fluid Overload in Falciparum Malaria	226
Jaundice in Falciparum Malaria	234
Anemia in Malaria and the Role of Blood Transfusion	237
Quinine Dosage and Serum Level in Falciparum Malaria	241
Evaluation of a Direct Counting Technique for Malaria in Thailand	251
Treatment of Severe Malaria in Children	253
A Study of Falciparum Malaria in Vietnam Using Serum Quinine Concentrations	255

PRINCIPAL INVESTIGATORS	256
PUBLICATIONS	258