TABLE OF CONTENTS
Introduction Air Vice Marshal Sithibun Purnaveja, MC, RTAF
Director General
Armed Forces Research Institute of Medical Sciences
Introduction LTC Herbert E. Segal, MC, USA
Director, US Army Medical Component
TROPICAL AND SUBTROPICAL DISEASES
Penicillin Resistant Neisseria gonorrhoeae Infection in Selected
Clinic Populations
3
Maternal Rectal and Vaginal Flora Associated with Infant
Colonization and Its Relationship to Diarrhea
9
Chemotherapy of Gnathostomiasis
18
Ectoparasite and Rickettsia tsutsugamushi Studies in Thailand
25
Mosquito Cytogenetic and Electrophoresis Studies
29
Mosquito Survey and Taxonomic Studies
34
Survey of Sylvatic Rodents for Serological Evidence of Rabies Virus
Infection
37
Survey of Sylvatic Rodents for Serological Evidence of Leptospirosis
41
Survey on the Incidence of Angiostrongylus sp. in Wild Rodents
42
A Survey for Viral Agents Transmitted by Culicoides in Northern
Thailand
45
Isolations of Dengue Viruses from Patients in Provincial Hospitals
46
A Serological Survey for Togaviruses (Arboviruses) in a Well
Defined Rural Thai Population
49
Isolation of Dengue Viruses from Leukocytes and Plasma of Dengue
Hemorrhagic Fever Patients
53
Dengue-2 Candidate Vaccine Studies : Challenge of Immunized
Monkeys with Southeast Asian Wild Type Viruses
57
Isolation of Influenza Viruses During the 1977-1978 Epidemic
63
Ecology and Epidemiology Studies of Dengue Viruses in Din Daeng,
Bangkok, Thailand
66
Virological and Pathological Observations of Dengue Virus
Replication in Subcutaneously Inoculated Rhesus Monkeys
80
Evaluation of Aedes aegypti, Armigeres subalbatus, and
Toxorhynchites splendens as Bioassay Hosts for Dengue
Viruses
85
Relationship of Temperature to the Replication of Dengue Viruses in
LLC-Mk2 Cell Cultures
91
A Longitudinal Serological Study of a Lower Socioeconomic School
Population
96
Seroepidemiologic Survey of Hepatitis B Virus Infection in a Rural
Thai Village
109
Transmission of Hepatitis B Virus by Exposure to Human Semen
Containing Hepatitis B Surface Antigen
115
Investigation of the Epidemiology and Microbiology of Wounds and
Wound Infections in the Royal Thai Army (RTA)
119
Epidemiological and Ecological Studies of Scrub Typhus in Royal
Thai Army Field Training Facilities
123
The Prevalence of Poliovirus Infection in a Lower Socioeconomic
School Population
130
Rubella Antibody Prevalence in Bangkok School Children
133
MALARIA STUDIES
Sporontocidal Effect of Antimalarials in P. vivax Malaria
139
Treatment of the Acute Attack of Malaria Caused by Plasmodium
vivax: A Comparison of Mefloquine with Standard Therapy
142
Treatment of Vivax Malaria with Sulfadoxine-Pyrimethamine and
with Pyrimethamine Alone
145
In vitro Evaluation of Antimalarial Drugs Against P. falciparum:
A New Technique
149
Evaluation of Experimental Antimalarial Drugs in Rhesus Monkeys
Infected with Plasmodium cynomolgi
(Blood Schizonticidal Tests)
153
Evaluation of Experimental Antimalarial Drugs for Radical Curative
Activity in the Rhesus Monkey
155
Comparative Study of WR 225448 and Primaquine in the
Plasmodium cynomolgi - Rhesus Monkey Radical Curative
Model
159
Lymphocytotoxic Factors in Malaria Patients
164
Responsiveness of Malaria Patient Leukocytes in Mixed Leukocyte
Culture (MLC)
166
Lymphokine Mediated Macrophage Activation as Demonstrated by
Enhanced Protein Synthesis
169
Glucosamine (14C) Uptake in Malaria Activated Human Macrophages
173
Transformation of Patient Lymphocytes by Selected Malaria
Antigens
176
Synthesis of Lymphocyte Blastogenic Factor by Sensitized
Lymphocytes from Malaria Patients
180
Continuous in vitro Cultivation of P. falciparum and Malaria Antigen
Isolation
183
Effect of Sera from Malaria Patients on Mitogen Responsiveness of
Normal Lymphocytes
185
Comparative Susceptibility of Anopheles maculatus and Anopheles
balabacensis to Plasmodium vivax
188
Longevity Studies on Malaria Infected Anopheles
191
PUBLICATIONS
193